You probably have seen an advice like this: when taking your Oral Artemether and lumefantrine antimalarial drugs, please take them with fatty foods! 

Why should you take them with fatty foods? 

Take them with fatty foods because the lumefantrine component of that drug is hydrophobic/lipophilic.

Absorption of the hydrophobic/lipophilic lumefantrine component varies widely between individuals and is greatly increased by fat coadministration.
Take them with fatty foods except you have Nausea symptoms. 

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